Catalytic Oligodeoxynucleotides Define a Key Regulatory Role for Early Growth Response Factor-1 in the Porcine Model of Coronary In-Stent Restenosis

C. Lowe, Harry; G. Fahmy, Roger; M. Kavurma, Mary; H. Baker, Andrew; N. Chesterman, Colin; M. Khachigian, Levon

doi:10.1161/hh2001.097867

Public

Catalytic Oligodeoxynucleotides Define a Key Regulatory Role for Early Growth Response Factor-1 in the Porcine Model of Coronary In-Stent Restenosis

Published in Circulation Research • Oct 12, 2001

Authors:

Harry C. Lowe

Roger G. Fahmy

Mary M. Kavurma

Abstract

Early growth response factor-1 (Egr-1) controls the expression of a growing number of genes involved in the pathogenesis of atherosclerosis and postangioplasty restenosis. Egr-1 is activated by diverse proatherogenic stimuli. As such, this transcription factor represents a key molecular target in ef...

Subject

Restenosis

Neointima

Vascular smooth muscle

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