Metabolism of [U-13 C]glucose in human brain tumors in vivo.

A Maher, Elizabeth; Marin-Valencia, Isaac; M Bachoo, Robert; Mashimo, Tomoyuki; Raisanen, Jack; J Hatanpaa, Kimmo; Jindal, Ashish; Mark Jeffrey, F; Choi, Changho; Madden, Christopher; Mathews, Dana; M Pascual, Juan; E Mickey, Bruce; R Malloy, Craig; J DeBerardinis, Ralph

doi:10.1002/nbm.2794

Public

Metabolism of [U-13 C]glucose in human brain tumors in vivo.

Shared by NobleBlocks on Nov 1, 2012 • 12:00 AM UTC

Authors:

Elizabeth A Maher

Isaac Marin-Valencia

Robert M Bachoo

Abstract

Glioblastomas and brain metastases demonstrate avid uptake of 2-[(18) F]fluoro-2-deoxyglucose by positron emission tomography and display perturbations of intracellular metabolite pools by (1) H MRS. These observations suggest that metabolic reprogramming contributes to brain tumor growth in vivo. T...

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