Metabolism of [U‐<sup>13</sup>C]glucose in human brain tumors <i>in vivo</i>

A. Maher, Elizabeth; Marin‐Valencia, Isaac; Bachoo, Robert; Mashimo, Tomoyuki; Raisanen, Jack; J. Hatanpaa, Kimmo; Jindal, Ashish; Mark H. Jeffrey, F.; Choi, Changho; J. Madden, Christopher; Mathews, Dana; M. Pascual, Juan; Mickey, Bruce; R. Malloy, Craig; J. DeBerardinis, Ralph

doi:10.1002/nbm.2794

Public

Metabolism of [U‐13C]glucose in human brain tumors in vivo

Published in NMR in Biomedicine • Mar 15, 2012

Authors:

Elizabeth A. Maher

Isaac Marin‐Valencia

Robert Bachoo

Abstract

Glioblastomas and brain metastases demonstrate avid uptake of 2-[(18) F]fluoro-2-deoxyglucose by positron emission tomography and display perturbations of intracellular metabolite pools by (1) H MRS. These observations suggest that metabolic reprogramming contributes to brain tumor growth in vivo. T...

Subject

Citric acid cycle

Glutamine

In vivo

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