Homozygosity mapping with SNP arrays identifies TRIM32 , an E3 ubiquitin ligase, as a Bardet–Biedl syndrome gene ( BBS11 )

The identification of mutations in genes that cause human diseases has largely been accomplished through the use of positional cloning, which relies on linkage mapping. In studies of rare diseases, the resolution of linkage mapping is limited by the number of available meioses and informative marker... View More