The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System

Nair, Madhavan; D. Mahajan, Supriya; L. Reynolds, Jessica; Aalinkeel, Ravikumar; Nair, Harikrishnan; A. Schwartz, Stanley; Kandaswami, Chithan

doi:10.1128/cvi.13.3.319-328.2006

Public

The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System

Published in Clinical and Vaccine Immunology • Mar 1, 2006

Authors:

Madhavan Nair

Supriya D. Mahajan

Jessica L. Reynolds

Abstract

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly unde...

Subject

Proinflammatory cytokine

Tumor necrosis factor alpha

Peripheral blood mononuclear cell

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