Regulation of Triglyceride Metabolism II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action

R. González-Baró, María; M. Lewin, Tal; Coleman, Rosalind

doi:10.1152/ajpgi.00553.2006

Public

Regulation of Triglyceride Metabolism II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • Dec 8, 2006

Authors:

María R. González-Baró

Tal M. Lewin

Rosalind Coleman

Abstract

GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. GPAT1 is upregulated transcriptionally by insulin and SREBP-1c and downregulated acutely by AMP-activated prot...

Subject

Steatosis

Lipid metabolism

Acyltransferase

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