Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, Kojiro; Suematsu, Ayako; Okamoto, Kazuo; Yamaguchi, Akira; Morishita, Yasuyuki; Kadono, Yuho; Tanaka, Sakae; Kodama, Tatsuhiko; Akira, Shizuo; Iwakura, Yoichiro; J. Cua, Daniel; Takayanagi, Hiroshi

doi:10.1084/jem.20061775

Public

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Published in The Journal of Experimental Medicine • Nov 6, 2006

Authors:

Kojiro Sato

Ayako Suematsu

Kazuo Okamoto

Abstract

In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhance osteoclastogenesis despite the anti-osteoclastogenic effect of interferon (IFN)-gamma remains to be elucidated. ...

Subject

T cell

Bone resorption

Immunology

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