Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

J. Moore, Kathryn; Kunjathoor, Vidya; L. Koehn, Stephanie; J. Manning, Jennifer; A. Tseng, Anita; M. Silver, Jessica; McKee, Mary; W. Freeman, Mason

doi:10.1172/jci24061

Public

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

Published in Journal of Clinical Investigation • Aug 1, 2005

Authors:

Kathryn J. Moore

Vidya Kunjathoor

Stephanie L. Koehn

Abstract

Macrophage internalization of modified lipoproteins is thought to play a critical role in the initiation of atherogenesis. Two scavenger receptors, scavenger receptor A (SR-A) and CD36, have been centrally implicated in this lipid uptake process. Previous studies showed that these receptors mediated...

Subject

CD36

Scavenger receptor

Foam cell

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