Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

Puel, Anne; Döffinger, Rainer; Natividad, Angels; Chrabieh, Maya; Barcenas‐Morales, Gabriela; Pïcard, Capucine; Cobat, Aurélie; Marie, O; Toulon, A.; Bustamante, Jacinta; Al‐Muhsen, Saleh; Al‐Owain, Mohammed; D. Arkwright, Peter; Costigan, Colm; McConnell, Vivienne; J. Cant, Andrew; Abinun, Mario; Polak, Michel; Bougnères, Pierre-François; Kumararatne, Dinakantha; Maródi, László; Nahum, Amit; M. Roifman, Chaim; Blanche, Stéphane; Fischer, Alain; Bodemer, Christine; Abel, Laurent; Lilić, Desa; Casanova, Jean‐Laurent

doi:10.1084/jem.20091983

Public

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

Published in The Journal of Experimental Medicine • Feb 1, 2010

Authors:

Anne Puel

Rainer Döffinger

Angels Natividad

Abstract

Most patients with autoimmune polyendocrine syndrome type I (APS-I) display chronic mucocutaneous candidiasis (CMC). We hypothesized that this CMC might result from autoimmunity to interleukin (IL)-17 cytokines. We found high titers of autoantibodies (auto-Abs) against IL-17A, IL-17F, and/or IL-22 i...

Subject

Chronic mucocutaneous candidiasis

Autoantibody

Immunology

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