ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Nishitoh, Hideki; Matsuzawa, Atsushi; Tobiume, Kei; Saegusa, Kaoru; Takeda, Kohsuke; Inoue, Kiyoshi; Hori, Seiji; Kakizuka, Akira; Ichijo, Hidenori

doi:10.1101/gad.992302

Public

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Published in Genes & Development • Jun 1, 2002

Authors:

Hideki Nishitoh

Atsushi Matsuzawa

Kei Tobiume

Abstract

Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease and spinocerebellar ataxias. PolyQ fragments accumulate as aggregates in the cytoplasm and/or in the nucleus, and indu...

Subject

Biology

Unfolded protein response

Programmed cell death

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!