Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

H. Kang, Min; Patrick Reynolds, C.

doi:10.1158/1078-0432.ccr-08-0144

Public

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

Published in Clinical Cancer Research • Feb 15, 2009

Authors:

Min H. Kang

C. Patrick Reynolds

Abstract

Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti-apoptotic B-cell lymphoma-2 (Bcl-2) family of proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1, Bfl1/A-1, and Bcl-B) that bind to ...

Subject

Bcl-2 family

Apoptosis

Cancer research

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