Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats

Finch, Jane; Suárez, Edu; Husain, Kazim; Ferder, León; C. Cardema, Michelle; J. Glenn, Denis; G. Gardner, David; Liapis, Helen; Slatopolsky, Eduardo

doi:10.1152/ajprenal.00293.2011

Public

Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats

Published in American Journal of Physiology-Renal Physiology • Sep 29, 2011

Authors:

Jane Finch

Edu Suárez

Kazim Husain

Abstract

Angiotensin-converting enzyme (ACE) inhibitors ameliorate the progression of renal disease. In combination with vitamin D receptor activators, they provide additional benefits. In the present study, uremic (U) rats were treated as follows: U+vehicle (UC), U+enalapril (UE; 25 mg/l in drinking water),...

Subject

Paricalcitol

Enalapril

Endocrinology

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