The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs

Suzawa, Tetsuo; Miyaura, Chisato; Inada, Masaki; Maruyama, Takayuki; Sugimoto, Yukihiko; Ushikubi, Fumitaka; Ichikawa, Atsushi; Narumiya, Shuh; Suda, Tatsuo

doi:10.1210/endo.141.4.7405

Public

The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs

Published in Endocrinology • Apr 1, 2000

Authors:

Tetsuo Suzawa

Chisato Miyaura

Masaki Inada

Abstract

PGE2 functions as a potent stimulator of bone resorption. The action of PGE2 is thought to be mediated by some PGE receptor subtypes present in osteoblastic cells. In this study, we examined the involvement of PGE receptor subtypes, EP1, EP2, EP3, and EP4, in PGE2-induced bone resorption using speci...

Subject

Prostaglandin E2 receptor

Calvaria

Bone resorption

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