Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, Ken; Wakabayashi, Nobunao; Katoh, Yasutake; Ishii, Tetsuro; Igarashi, Kazuhiko; Douglas Engel, James; Yamamoto, Masayuki

doi:10.1101/gad.13.1.76

Public

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Published in Genes & Development • Jan 1, 1999

Authors:

Ken Itoh

Nobunao Wakabayashi

Yasutake Katoh

Abstract

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of differential Nrf2 activity displayed in transfected cell lines ultimately led to the identification of a new protein,...

Subject

KEAP1

Biology

Transcription factor

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