Randomized Phase III Study of High-Dose Fluorouracil Given As a Weekly 24-Hour Infusion With or Without Leucovorin Versus Bolus Fluorouracil Plus Leucovorin in Advanced Colorectal Cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952

Köhne, C-H; Wils, J.; Lorenz, M.; Schöffski, Patrick; Voigtmann, R.; Bokemeyer, Carsten; P. Lutz, Manfred; R. Kleeberg, Ulrich; Ridwelski, Karsten; Souchon, R.; Elserafi, M.; Weiss, U.; Burkhard, Oswald; Rückle, H.; Lichinitser, Mikhail; Langenbuch, T.; Scheithauer, Werner; Barón, B.; Couvreur, M.L.; Schmoll, Hans‐Joachim

doi:10.1200/jco.2003.11.122

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Randomized Phase III Study of High-Dose Fluorouracil Given As a Weekly 24-Hour Infusion With or Without Leucovorin Versus Bolus Fluorouracil Plus Leucovorin in Advanced Colorectal Cancer: European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952

Published in Journal of Clinical Oncology • Sep 9, 2003

Authors:

C-H Köhne

J. Wils

M. Lorenz

Abstract

PURPOSE: This trial was conducted to determine whether high-dose fluorouracil (FU) given as a weekly 24-hour infusion is more active than bolus FU + leucovorin (LV), and whether high-dose infusional FU can be modulated by LV. PATIENTS AND METHODS: A total of 497 patients with previously untreated me...

Subject

Medicine

Fluorouracil

Bolus (digestion)

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