Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes.

Adaikalakoteswari, Antonysunil; Finer, Sarah; D Voyias, Philip; M McCarthy, Ciara; Vatish, Manu; Moore, Jonathan; Smart-Halajko, Melissa; Bawazeer, Nahla; M Al-Daghri, Nasser; G McTernan, Philip; Kumar, Sudhesh; A Hitman, Graham; Saravanan, Ponnusamy; Tripathi, Gyanendra

doi:10.1186/s13148-015-0046-8

Public

Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes.

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

Antonysunil Adaikalakoteswari

Sarah Finer

Philip D Voyias

Abstract

BACKGROUND: The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that vitamin B12 deficiency is associated with alte...

Subject

Adipocyte

Cholesterol

Folic acid

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