Synthetic Malaria Peptide Vaccine Elicits High Levels of Antibodies in Vaccinees of Defined HLA Genotypes

Nardin, Elizabeth; A. Oliveira, Giane; Mauricio Calvo‐Calle, J.; Castro, Z; S Nussenzweig, R; J. Schmeckpeper, Barbara; Hall, Bradford; L. Diggs, Carter; A Bodison, Sacared; Edelman, Robert

doi:10.1086/315871

Public

Synthetic Malaria Peptide Vaccine Elicits High Levels of Antibodies in Vaccinees of Defined HLA Genotypes

Published in The Journal of Infectious Diseases • Nov 1, 2000

Authors:

Elizabeth Nardin

Giane A. Oliveira

J. Mauricio Calvo‐Calle

Abstract

A multiple antigen peptide (MAP) malaria vaccine containing minimal Plasmodium falciparum circumsporozoite protein repeat epitopes was assessed for safety and immunogenicity in volunteers of known class II genotypes. The MAP/alum/QS-21 vaccine formulation elicited high levels of parasite-specific an...

Subject

Circumsporozoite protein

Immunogenicity

Epitope

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