Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

D’Andrea, Annalisa; Aste-Amézaga, Miguel; M. Valiante, Nicholas; Ma, Xiaojing; Kubin, Marek; Trinchieri, Giorgio

doi:10.1084/jem.178.3.1041

Public

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

Published in The Journal of Experimental Medicine • Sep 1, 1993

Authors:

Annalisa D’Andrea

Miguel Aste-Amézaga

Nicholas M. Valiante

Abstract

Natural killer cell stimulatory factor or interleukin 12 (NKSF/IL-12) is a heterodimeric cytokine produced by monocytes/macrophages, B cells, and possibly other accessory cell types primarily in response to bacteria or bacterial products. NKSF/IL-12 mediates pleiomorphic biological activity on T and...

Subject

Cytokine

Interleukin 12

Biology

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