Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan

Chen, Pei‐Jer; Lin, Juei‐Jueng; Lu, Chin‐Song; Ong, Cheung-Ter; F. Hsieh, Peiyuan; Yang, Chih‐Chao; Tai, Chih‐Ta; Wu, Shey‐Lin; Lu, Cheng‐Hsien; Hsu, Yung‐Chu; Yu, Hsiang‐Yu; Ro, Long‐Sun; Lu, C.‐H.; Chu, Chun‐Che; Tsai, Jing‐Jane; Su, Yu-Hsiang; Lan, Sheng‐Hsing; Sung, Sheng‐Feng; Lin, Shu‐Yi; Chuang, Hui-Ping; Huang, Ying‐Zu; Chen, Ying‐Ju; Tsai, Pei-Joung; Liao, Hung-Ting; Lin, Yu‐Hsuan; Chen, Chien-Hsiun; Chung, Wen‐Hung; Chung, Wen‐Hung; Wu, Jer‐Yuarn; Chang, Chi‐Feng; Chen, Liming; Chen, Yuan-Tsong; Shen, Chen‐Yang

doi:10.1056/nejmoa1009717

Public

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan

Published in New England Journal of Medicine • Mar 23, 2011

Authors:

Pei‐Jer Chen

Juei‐Jueng Lin

Chin‐Song Lu

Abstract

BACKGROUND: Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. ...

Subject

Carbamazepine

Medicine

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