Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia

W.J. van der Schaft, Daisy; Hillen, Femke; Pauwels, Patrick; A. Kirschmann, Dawn; Castermans, Karolien; G.A. oude Egbrink, Mirjam; Tran, Maxine; Sciot, Raf; Hauben, Esther; C.W. Hogendoorn, Pancras; Delattre, Olivier; H. Maxwell, Patrick; J.C. Hendrix, Mary; W. Griffioen, Arjan

doi:10.1158/0008-5472.can-05-2468

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Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia

Published in Cancer Research • Dec 15, 2005

Authors:

Daisy W.J. van der Schaft

Femke Hillen

Patrick Pauwels

Abstract

A striking feature of Ewing sarcoma is the presence of blood lakes lined by tumor cells. The significance of these structures, if any, is unknown. Here, we report that the extent of blood lakes correlates with poor clinical outcomes, whereas variables of angiogenesis do not. We also show that Ewing ...

Subject

Vasculogenic mimicry

Sarcoma

Ewing's sarcoma

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