Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

S. Berghoff, Anna; Kiesel, Barbara; Widhalm, Georg; Rajky, Orsolya; Ricken, Gerda; Wöhrer, Adelheid; Dieckmann, Karin; Filipits, Martin; Brandstetter, Anita; Weller, Michael; Kurscheid, Sebastian; E. Hegi, Monika; Zielinski, Christoph; Marosi, Christine; A. Hainfellner, Johannes; Preusser, Matthias; Wick, Wolfgang

doi:10.1093/neuonc/nou307

Public

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

Published in Neuro-Oncology • Oct 29, 2014

Authors:

Anna S. Berghoff

Barbara Kiesel

Georg Widhalm

Abstract

BACKGROUND: Immune checkpoint inhibitors targeting programmed cell death 1 (PD1) or its ligand (PD-L1) showed activity in several cancer types. METHODS: We performed immunohistochemistry for CD3, CD8, CD20, HLA-DR, phosphatase and tensin homolog (PTEN), PD-1, and PD-L1 and pyrosequencing for assessm...

Subject

PTEN

Tensin

Tumor-infiltrating lymphocytes

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