Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Gobert, Michael; Treilleux, Isabelle; Bendriss-Vermare, Nathalie; Bachelot, Thomas; Goddard-Leon, Sophie; Arfi, Vanessa; Biota, Cathy; Claire Doffin, Anne; Durand, Isabelle; Olive, Daniel; Perez, Solène; Pasqual, Nicolas; Faure, Christelle; Ray-Coquard, Isabelle; Puisieux, Alain; Caux, Christophe; Blay, Jean-Yves; Ménétrier-Caux, Christine

doi:10.1158/0008-5472.can-08-2360

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Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Shared by NobleBlocks on Mar 1, 2009 • 12:00 AM UTC

Authors:

Michael Gobert

Isabelle Treilleux

Nathalie Bendriss-Vermare

Abstract

Abstract Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates surrounding the tumor was predictive of relapse and death, in contrast to those present within the tumor bed. Ex vivo analy...

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