Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.

A O'Brien, Charles; Jia, Dan; I Plotkin, Lilian; Bellido, Teresita; C Powers, Cara; A Stewart, Scott; C Manolagas, Stavros; S Weinstein, Robert

doi:10.1210/en.2003-0990

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Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.

Shared by NobleBlocks on Apr 1, 2004 • 12:00 AM UTC

Authors:

Charles A O'Brien

Dan Jia

Lilian I Plotkin

Abstract

Whether the negative impact of excess glucocorticoids on the skeleton is due to direct effects on bone cells, indirect effects on extraskeletal tissues, or both is unknown. To determine the contribution of direct effects of glucocorticoids on osteoblastic/osteocytic cells in vivo, we blocked glucoco...

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