Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin.

PA, Zucali; E, Giovannetti; A, Destro; M, Mencoboni; GL, Ceresoli; L, Gianoncelli; E, Lorenzi; Vincenzo F, De; M, Simonelli; M, Perrino; A, Bruzzone; E, Thunnissen; G, Tunesi; L, Giordano; M, Roncalli; GJ, Peters; A, Santoro

doi:10.1158/1078-0432.ccr-10-2873

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Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed/carboplatin.

Shared by NobleBlocks on Jan 24, 2011 • 12:00 AM UTC

Authors:

Zucali PA

Giovannetti E

Destro A

Abstract

Purpose The pemetrexed/platinum agent combination represents the standard of care in first-line treatment for malignant pleural mesothelioma (MPM). However, there are no established indicators of responsiveness that can be used to optimize the treatment. This retrospective study aimed to assess the ...

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