Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

Amirouche, Adel; Durieux, Anne‐Cécile; Banzet, Sébastien; Koulmann, Nathalie; Bonnefoy, Régis; Mouret, Catherine; Bigard, Xavier; Peinnequin, André; Freyssenet, Damien

doi:10.1210/en.2008-0959

Public

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

Published in Endocrinology • Sep 18, 2008

Authors:

Adel Amirouche

Anne‐Cécile Durieux

Sébastien Banzet

Abstract

Myostatin, a member of the TGF-beta family, has been identified as a master regulator of embryonic myogenesis and early postnatal skeletal muscle growth. However, cumulative evidence also suggests that alterations in skeletal muscle mass are associated with dysregulation in myostatin expression and ...

Subject

Myostatin

Protein kinase B

PI3K/AKT/mTOR pathway

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