Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke<i>in vitro</i>

Milara, Javier; Armengot, M; Bañuls, P; Tenor, Hermann; Beume, Rolf; Artigues, Enrique; Cortijo, Julio

doi:10.1111/j.1476-5381.2012.01929.x

Public

Roflumilast N‐oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smokein vitro

Published in British Journal of Pharmacology • Mar 5, 2012

Authors:

Javier Milara

M Armengot

P Bañuls

Abstract

BACKGROUND AND PURPOSE: Mucociliary malfunction occurs in chronic obstructive pulmonary disease (COPD) and compromised functions of ciliated bronchial epithelial cells may contribute to this. Cigarette smoke, a major risk factor for COPD, impairs ciliary beat frequency (CBF). cAMP augments CBF. This...

Subject

Roflumilast

Motility

In vitro

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