PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease

Salameh, Habeeb; Raff, Evan; Erwin, Angelika; Seth, Devanshi; Dieter Nischalke, Hans; Falleti, Edmondo; Antonella Burza, Maria; Leathert, Julian; Romeo, Stefano; Molinaro, Antonio; Ginanni Corradini, Stefano; Toniutto, Pierluigi; Spengler, Ulrich; K. Daly, Ann; P. Day, Christopher; Kuo, Yong‐Fang; K. Singal, Ashwani

doi:10.1038/ajg.2015.137

Public

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease

Published in The American Journal of Gastroenterology • May 12, 2015

Authors:

Habeeb Salameh

Evan Raff

Angelika Erwin

Abstract

OBJECTIVES: The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis. PNPLA3 polymorphism is shown to be associated with alcoholic liver disease (ALD). We performed...

Subject

Medicine

Internal medicine

Alcoholic liver disease

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