Adipose Mitochondrial Biogenesis Is Suppressed in <i>db/db</i> and High-Fat Diet–Fed Mice and Improved by Rosiglitazone

X. Rong, James; Qiu, Yang; K. Hansen, Michael; Zhu, Lei; Zhang, Vivian; Xie, Mi; Okamoto, Yuji; Mattie, Michael; Higashiyama, Hiroyuki; Asano, S; C. Strum, Jay; E. Ryan, Terence

doi:10.2337/db06-1135

Public

Adipose Mitochondrial Biogenesis Is Suppressed in db/db and High-Fat Diet–Fed Mice and Improved by Rosiglitazone

Published in Diabetes • Jun 27, 2007

Authors:

James X. Rong

Yang Qiu

Michael K. Hansen

Abstract

The objective of this study was to further establish and confirm the relationship of adipose mitochondrial biogenesis in diabetes/obesity and the effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor (PPAR) gamma agonist, by systematically analyzing mitochondrial gene expressi...

Subject

Mitochondrial biogenesis

TFAM

Citrate synthase

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