Nonstructural Nipah Virus C Protein Regulates both the Early Host Proinflammatory Response and Viral Virulence

Mathieu, Cyrille; Guillaume, Vanessa; A. Volchkova, Valentina; Pohl, Christine; Jacquot, Frederique; Looi, R.Y.; Thong Wong, Kum; Legras‐Lachuer, Catherine; E. Volchkov, Viktor; Lachuer, Joël; Horvat, Branka

doi:10.1128/jvi.01203-12

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Nonstructural Nipah Virus C Protein Regulates both the Early Host Proinflammatory Response and Viral Virulence

Published in Journal of Virology • Jul 27, 2012

Authors:

Cyrille Mathieu

Vanessa Guillaume

Valentina A. Volchkova

Abstract

Nipah virus (NiV) is a highly pathogenic, negative-strand RNA paramyxovirus that has recently emerged from flying foxes to cause serious human disease. We have analyzed the role of the nonstructural NiV C protein in viral immunopathogenesis using recombinant virus lacking the expression of NiV C (Ni...

Subject

Proinflammatory cytokine

Biology

Chemokine

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