A novel electrospun biphasic scaffold provides optimal three-dimensional topography for <i>in vitro</i> co-culture of airway epithelial and fibroblast cells

E Morris, G; C. Bridge, Jack; A Brace, L; J. Knox, Alan; W. Aylott, Jonathan; E. Brightling, Christopher; M. Ghaemmaghami, Amir; R. A. J. Rose, Felicity

doi:10.1088/1758-5082/6/3/035014

Public

A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells

Published in Biofabrication • Jun 13, 2014

Authors:

G E Morris

Jack C. Bridge

L A Brace

Abstract

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to produce defined, porous 3D matrices for cell culture....

Subject

Scaffold

Materials science

Fibroblast

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