Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

Bonecchi, Raffaella; Bianchi, Giancarlo; Panina‐Bordignon, Paola; D’Ambrosio, Daniele; Lang, Rosmarie; Borsatti, Alessandro; Sozzani, Silvano; Allavena, Paola; A. Gray, Patrick; Mantovani, Alberto; Sinigaglia, Francesco

doi:10.1084/jem.187.1.129

Public

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

Published in The Journal of Experimental Medicine • Jan 5, 1998

Authors:

Raffaella Bonecchi

Giancarlo Bianchi

Paola Panina‐Bordignon

Abstract

T helper cells type 1 (Th1s) that produce interferon-gamma predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which produce large amounts of IL-4 and IL-5 upregulate IgE production and are prominent in the pathogenesis...

Subject

CCL13

CCR1

Chemokine receptor

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