Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines

Li, Xiang; Wen, Weihong; Liu, Kangdong; Zhu, Feng; Malakhova, Margarita; Peng, Cong; Li, Tingting; Kim, Hong-Gyum; Ma, Weiya; Yeon Cho, Yong; M. Bode, Ann; Dong, Ziming; Dong, Zigang

doi:10.1074/jbc.m111.236596

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Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines

Published in Journal of Biological Chemistry • May 10, 2011

Authors:

Xiang Li

Weihong Wen

Kangdong Liu

Abstract

p21-activated kinase (PAK) 2, a member of the PAK family of serine/threonine protein kinases, plays an important role in physiological processes such as motility, survival, mitosis, and apoptosis. However, the role of PAK2 in resistance to chemotherapy is unclear. Here we report that PAK2 is highly ...

Subject

Kinase

Phosphorylation

Cancer research

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