Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

A. Hindorff, Lucia; Sethupathy, Praveen; Junkins, Heather; M. Ramos, Erin; P. Mehta, Jayashri; S. Collins, Francis; A. Manolio, Teri

doi:10.1073/pnas.0903103106

Public

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Published in Proceedings of the National Academy of Sciences • May 27, 2009

Authors:

Lucia A. Hindorff

Praveen Sethupathy

Heather Junkins

Abstract

We have developed an online catalog of SNP-trait associations from published genome-wide association studies for use in investigating genomic characteristics of trait/disease-associated SNPs (TASs). Reported TASs were common [median risk allele frequency 36%, interquartile range (IQR) 21%-53%] and w...

Subject

Genome-wide association study

Single-nucleotide polymorphism

Genetics

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