Concentration-Dependent
                    <i>Mycobacterium tuberculosis</i>
                    Killing and Prevention of Resistance by Rifampin

Gumbo, Tawanda; Louie, Arnold; R. Deziel, Mark; Liu, Weiguo; M. Parsons, Linda; Salfinger, Max; L. Drusano, George

doi:10.1128/aac.01533-06

Public

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

Shared by NobleBlocks on Nov 1, 2007 • 12:00 AM UTC

Authors:

Tawanda Gumbo

Arnold Louie

Mark R. Deziel

Abstract

ABSTRACT Rifampin is a cornerstone of modern antituberculosis therapy. However, rifampin's half-life of 3 h is believed to limit its utility for intermittent therapy, so new congeners with long half-lives are being developed. Using an in vitro pharmacokinetic-pharmacodynamic model of tuberculosis, w...

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