Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

Matias, Isabel; Gonthier, Marie-Paule; Orlando, Pierangelo; Martiadis, Vassilis; De Petrocellis, Luciano; Cervino, Cristina; Petrosino, Stefania; Hoareau, Laurence; Festy, Franck; Pasquali, Renato; Roche, Regis; Maj, Mario; Pagotto, Uberto; Monteleone, Palmiero; Di Marzo, Vincenzo

doi:10.1210/jc.2005-2679

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Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

Shared by NobleBlocks on Aug 1, 2006 • 12:00 AM UTC

Authors:

Isabel Matias

Marie-Paule Gonthier

Pierangelo Orlando

Abstract

Abstract Context: Cannabinoid CB1 receptor blockade decreases weight and hyperinsulinemia in obese animals and humans in a way greatly independent from food intake. Objective: The objective of this study was to investigate the regulation and function of the endocannabinoid system in adipocytes and p...

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