Genome-wide association analysis reveals a <i>SOD1</i> mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

Awano, Tomoyuki; S. Johnson, Gary; M. Wade, Claire; L. Katz, Martin; C. Johnson, Gayle; F. Taylor, Jeremy; Perloski, Michele; Biagi, Tara; Baranowska, Izabella; Long, Sam; A. March, Philip; J. Olby, Natasha; Diane Shelton, G.; Khan, Shahnawaz; P. O’Brien, Dennis; Lindblad‐Toh, Kerstin; R. Coates, Joan

doi:10.1073/pnas.0812297106

Public

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

Published in Proceedings of the National Academy of Sciences • Feb 2, 2009

Authors:

Tomoyuki Awano

Gary S. Johnson

Claire M. Wade

Abstract

Canine degenerative myelopathy (DM) is a fatal neurodegenerative disease prevalent in several dog breeds. Typically, the initial progressive upper motor neuron spastic and general proprioceptive ataxia in the pelvic limbs occurs at 8 years of age or older. If euthanasia is delayed, the clinical sign...

Subject

Amyotrophic lateral sclerosis

SOD1

Pathology

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