Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1

Chen, Shuang; Dai, Yun; Pei, Xin‐Yan; Grant, Steven

doi:10.1128/mcb.01481-08

Public

Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-xL, and Mcl-1

Published in Molecular and Cellular Biology • Oct 6, 2009

Authors:

Shuang Chen

Yun Dai

Xin‐Yan Pei

Abstract

The Bcl-2 antagonist ABT-737 kills transformed cells in association with displacement of Bim from Bcl-2. The histone deactetylase (HDAC) inhibitor suberoyl bis-hydroxamic acid (SBHA) was employed to determine whether and by what mechanism ABT-737 might interact with agents that upregulate Bim. Expre...

Subject

Puma

Downregulation and upregulation

Biology

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