Persistent immune activation in HIV-1 infection is associated with progression to AIDS

D. Hazenberg, Mette; A. Otto, Sigrid; HB van Benthem, Birgit; Roos, Marijke; A. Coutinho, Roel; MA Lange, Joep; Hamann, Dörte; Prins, Maria; Miedema, Frank

doi:10.1097/00002030-200309050-00006

Public

Persistent immune activation in HIV-1 infection is associated with progression to AIDS

Published in AIDS • Aug 27, 2003

Authors:

Mette D. Hazenberg

Sigrid A. Otto

Birgit HB van Benthem

Abstract

BACKGROUND: HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood. OBJECTIVE: To study the relation between chronic immune activation and CD4 T cell depletion in HIV-1 infection. DESIGN: Prospective cohort study a...

Subject

Immunology

Human immunodeficiency virus (HIV)

Immunopathology

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