A Novel Locus, <i>Mody4</i>, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice

Yoshioka, Masato; Kayo, Tsuyoshi; Ikeda, Tsurumi; Koizuni, Akio

doi:10.2337/diab.46.5.887

Public

A Novel Locus, Mody4, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice

Published in Diabetes • May 1, 1997

Authors:

Masato Yoshioka

Tsuyoshi Kayo

Tsurumi Ikeda

Abstract

In this article, we report on a nonobese C57BL/6 (B6) mouse model of NIDDM named Akita mouse, characterized by early age onset and autosomal dominant mode of inheritance. At 7 weeks of age, the mean morning blood glucose levels (mmol/l) under ad libitum feeding conditions were significantly higher (...

Subject

Endocrinology

Internal medicine

Insulitis

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