A randomized comparison of nativeEscherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study

I. Avramis, Vassilios; Sencer, Susan; Periclou, Antonia; N. Sather, Harland; Bostrom, Bruce; Cohen, Lewis; G. Ettinger, Alice; J. Ettinger, Lawrence; Franklin, Janet; S. Gaynon, Paul; M. Hilden, Joanne; J. Lange, Beverly; Majlessipour, Fataneh; Mathew, Pracad; N. Needle, Michael; P. Neglia, Joseph; H. Reaman, Gregory; S. Holcenberg, John

doi:10.1182/blood.v99.6.1986

Public

A randomized comparison of nativeEscherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study

Published in Blood • Mar 15, 2002

Authors:

Vassilios I. Avramis

Susan Sencer

Antonia Periclou

Abstract

For this study, 118 children with standard-risk acute lymphoblastic leukemia (ALL) were given randomized assignments to receive native or pegylated Escherichia coli asparaginase as part of induction and 2 delayed intensification phases. Patients treated with pegaspargase had more rapid clearance of ...

Subject

Asparaginase

Medicine

Acute lymphocytic leukemia

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