Recurrent epimutation of<i>SDHC</i>in gastrointestinal stromal tumors

Keith Killian, Jonathan; Miettinen, Markku; L. Walker, Robert; Wang, Yonghong; J. Zhu, Yuelin; J. Waterfall, Joshua; Noyes, Natalia; Retnakumar, Parvathy; Yang, Zhiming; I. Smith, William; Scott Killian, M.; Lau, Christopher; Pineda, Marbin; Walling, Jennifer; Stevenson, Holly; Smith, Carly; Wang, Zengfeng; Lasota, Jerzy; Young Kim, Su; A. Boikos, Sosipatros; J. Helman, Lee; S. Meltzer, Paul

doi:10.1126/scitranslmed.3009961

Public

Recurrent epimutation ofSDHCin gastrointestinal stromal tumors

Published in Science Translational Medicine • Dec 24, 2014

Authors:

Jonathan Keith Killian

Markku Miettinen

Robert L. Walker

Abstract

Succinate dehydrogenase (SDH) is a conserved effector of cellular metabolism and energy production, and loss of SDH function is a driver mechanism in several cancers. SDH-deficient gastrointestinal stromal tumors (dSDH GISTs) collectively manifest similar phenotypes, including hypermethylated epigen...

Subject

Stromal cell

Cancer research

Methylation

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