Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

Volckaert, Thomas; Dill, Erik; Campbell, Alice; Tiozzo, Caterina; M. Majka, Susan; Bellusci, Savério; De Langhe, Stijn

doi:10.1172/jci58097

Public

Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

Published in Journal of Clinical Investigation • Oct 10, 2011

Authors:

Thomas Volckaert

Erik Dill

Alice Campbell

Abstract

During lung development, parabronchial SMC (PSMC) progenitors in the distal mesenchyme secrete fibroblast growth factor 10 (Fgf10), which acts on distal epithelial progenitors to promote their proliferation. β-catenin signaling within PSMC progenitors is essential for their maintenance, proliferatio...

Subject

Wnt signaling pathway

Cell biology

Paracrine signalling

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