Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

G. Emery, John; McDonnell, Peter; Brigham Burke, Michael; C. Deen, Keith; D. Lyn, Sally; Silverman, Carol; Dul, Edward; R. Appelbaum, Edward; Eichman, Chris; DiPrinzio, Rocco; A. Dodds, Robert; E. James, Ian; Rosenberg, Martin; C. Lee, John; R. Young, Peter

doi:10.1074/jbc.273.23.14363

Public

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

Published in Journal of Biological Chemistry • Jun 1, 1998

Authors:

John G. Emery

Peter McDonnell

Michael Brigham Burke

Abstract

TRAIL is a tumor necrosis factor-related ligand that induces apoptosis upon binding to its death domain-containing receptors, DR4 and DR5. Two additional TRAIL receptors, TRID/DcR1 and DcR2, lack functional death domains and function as decoy receptors for TRAIL. We have identified a fifth TRAIL rec...

Subject

Osteoprotegerin

Tumor necrosis factor alpha

Receptor

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