A Novel Intramuscular Bivalent Norovirus Virus-Like Particle Vaccine Candidate—Reactogenicity, Safety, and Immunogenicity in a Phase 1 Trial in Healthy Adults

J. Treanor, John; L. Atmar, Robert; E. Frey, Sharon; Gormley, Robert; H. Chen, Wilbur; Ferreira, Jennifer; R. Goodwin, Robert; Borkowski, Astrid; Clemens, Ralf; M. Mendelman, Paul

doi:10.1093/infdis/jiu337

Public

A Novel Intramuscular Bivalent Norovirus Virus-Like Particle Vaccine Candidate—Reactogenicity, Safety, and Immunogenicity in a Phase 1 Trial in Healthy Adults

Published in The Journal of Infectious Diseases • Jun 20, 2014

Authors:

John J. Treanor

Robert L. Atmar

Sharon E. Frey

Abstract

BACKGROUND: Noroviruses are the most important viral causes of gastroenteritis-related morbidity and mortality. A randomized, double-blind, placebo-controlled study evaluated an adjuvanted bivalent intramuscular norovirus virus-like particle (VLP) vaccine. METHODS: Forty-eight adults aged 18-49 year...

Subject

Reactogenicity

Immunogenicity

Medicine

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