CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

D. Kirk, Allan; M. Harlan, David; Armstrong, Nicholas; A. Davis, Thomas; Dong, Yinchen; S. Gray, Gary; Hong, Xuening; W. Thomas, David; H. Fechner, John; J. Knechtle, Stuart

doi:10.1073/pnas.94.16.8789

Public

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

Published in Proceedings of the National Academy of Sciences • Aug 5, 1997

Authors:

Allan D. Kirk

David M. Harlan

Nicholas Armstrong

Abstract

Selective inhibition of T cell costimulation using the B7-specific fusion protein CTLA4-Ig has been shown to induce long-term allograft survival in rodents. Antibodies preventing the interaction between CD40 and its T cell-based ligand CD154 (CD40L) have been shown in rodents to act synergistically ...

Subject

Mixed lymphocyte reaction

Immunology

Major histocompatibility complex

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