Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

J. Molenaar, Jan; Köster, Jan; A. Zwijnenburg, Danny; van Sluis, Peter; J. Valentijn, Linda; van der Ploeg, Ida; Hamdi, Mohamed; van Nes, Johan; A. Westerman, Bart; van Arkel, Jennemiek; E. Ebus, Marli; Haneveld, Franciska; Lakeman, Arjan; Schild, Linda; Molenaar, Piet; Stroeken, Peter; M. van Noesel, Max; Øra, Ingrid; E. Santo, Evan; N. Caron, Huib; M. Westerhout, Ellen; Versteeg, Rogier

doi:10.1038/nature10910

Public

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

Published in Nature • Feb 21, 2012

Authors:

Jan J. Molenaar

Jan Köster

Danny A. Zwijnenburg

Abstract

Whole-genome sequencing of neuroblastoma, a childhood tumour of the nervous system, shows that chromothripsis (a local shredding of chromosomes) and mutations in genes regulating neurite growth are associated with the most aggressive tumours. Whole-genome sequencing is used here to identify genetic ...

Subject

Neuroblastoma

Chromothripsis

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