UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.

Sai, Kimie; Saeki, Mayumi; Saito, Yoshiro; Ozawa, Shogo; Katori, Noriko; Jinno, Hideto; Hasegawa, Ryuichi; Kaniwa, Nahoko; Sawada, Jun-ichi; Komamura, Kazuo; Ueno, Kazuyuki; Kamakura, Shiro; Kitakaze, Masafumi; Kitamura, Yutaka; Kamatani, Naoyuki; Minami, Hironobu; Ohtsu, Atsushi; Shirao, Kuniaki; Yoshida, Teruhiko; Saijo, Nagahiro

doi:10.1016/j.clpt.2004.01.010

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UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.

Shared by NobleBlocks on Jun 1, 2004 • 12:00 AM UTC

Authors:

Kimie Sai

Mayumi Saeki

Yoshiro Saito

Abstract

PURPOSE: A comprehensive haplotype analysis of UGT1A1 in the Japanese population was conducted, and the effects of these haplotypes were investigated with respect to UGT1A1-related phenotypic parameters in patients with cancer who received irinotecan. METHODS: The UGT1A1 gene, including the enhancer...

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