Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

G Bauernfeind, Franz; Horvath, Gabor; Stutz, Andrea; S Alnemri, Emad; MacDonald, Kelly; Speert, David; Fernandes-Alnemri, Teresa; Wu, Jianghong; G Monks, Brian; A Fitzgerald, Katherine; Hornung, Veit; Latz, Eicke

doi:10.4049/jimmunol.0901363

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Shared by NobleBlocks on Jul 1, 2009 • 12:00 AM UTC

Authors:

Franz G Bauernfeind

Gabor Horvath

Andrea Stutz

Abstract

Abstract The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine receptors control pro-IL-1β transcription whereas inflammasomes regulate the proteolytic processing of pro-IL-1β. The NLRP3 inflammasome, however, assembles in respons...

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