Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, Franz; Horváth, Gábor; Stutz, Andrea; S. Alnemri, Emad; L. MacDonald, Kelly; P. Speert, David; Fernandes‐Alnemri, Teresa; Wu, Jianghong; G. Monks, Brian; A. Fitzgerald, Katherine; Hornung, Veit; Latz, Eicke

doi:10.4049/jimmunol.0901363

Public

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Published in The Journal of Immunology • Jul 1, 2009

Authors:

Franz Bauernfeind

Gábor Horváth

Andrea Stutz

Abstract

The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine receptors control pro-IL-1beta transcription whereas inflammasomes regulate the proteolytic processing of pro-IL-1beta. The NLRP3 inflammasome, however, assembles in response t...

Subject

Inflammasome

Cell biology

Receptor

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