Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

Sotiriou, Christos; Wirapati, Pratyaksha; Loi, Sherene; L. Harris, Adrian; Fox, Steve; Smeds, Johanna; Nordgren, Hans; Farmer, Pierre; Praz, Viviane; Haibe‐Kains, Benjamin; Desmedt, Christine; Larsimont, Denis; Cardoso, Fátima; Peterse, Hans; S.A. Nuyten, Dimitry; Buyse, Marc; J. van de Vijver, Marc; Bergh, Jonas; Piccart, Martine; Delorenzi, Mauro

doi:10.1093/jnci/djj052

Public

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

Published in JNCI Journal of the National Cancer Institute • Feb 14, 2006

Authors:

Christos Sotiriou

Pratyaksha Wirapati

Sherene Loi

Abstract

BACKGROUND: Histologic grade in breast cancer provides clinically important prognostic information. However, 30%-60% of tumors are classified as histologic grade 2. This grade is associated with an intermediate risk of recurrence and is thus not informative for clinical decision making. We examined ...

Subject

Grading (engineering)

Breast cancer

Gene expression profiling

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