OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

D. Curti, Brendan; Kovacsovics-Bankowski, Magdalena; Morris, Nicholas; Walker, Edwin; Chisholm, Lana; Floyd, Kevin; Walker, Joshua; Gonzalez, Iliana; Meeuwsen, Tanisha; A. Fox, Bernard; Moudgil, Tarsem; Miller, William; Haley, Daniel; Coffey, Todd; Fisher, Brenda; Delanty-Miller, Laurie; Rymarchyk, Nicole; Kelly, Tracy; Crocenzi, Todd; Bernstein, Eric; Sanborn, Rachel; J. Urba, Walter; D. Weinberg, Andrew

doi:10.1158/0008-5472.can-12-4174

Public

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

Shared by NobleBlocks on Dec 15, 2013 • 12:00 AM UTC

Authors:

Brendan D. Curti

Magdalena Kovacsovics-Bankowski

Nicholas Morris

Abstract

Abstract OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferat...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!