OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

D. Curti, Brendan; Kovacsovics-Bankowski, Magdalena; P. Morris, Nicholas; Walker, Edwin; Chisholm, Lana; Floyd, Kevin; M. Walker, Joshua; L. Gonzalez, Iliana; Meeuwsen, Tanisha; A. Fox, Bernard; Moudgil, Tarsem; L. Miller, William; Haley, Daniel; Coffey, Todd; Fisher, Brenda; Delanty-Miller, Laurie; Rymarchyk, Nicole; L. Kelly, Tracy; S. Crocenzi, Todd; Bernstein, Eric; E. Sanborn, Rachel; J. Urba, Walter; D. Weinberg, Andrew

doi:10.1158/0008-5472.can-12-4174

Public

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

Published in Cancer Research • Nov 1, 2013

Authors:

Brendan D. Curti

Magdalena Kovacsovics-Bankowski

Nicholas P. Morris

Abstract

OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effe...

Subject

FOXP3

Immune system

Cancer research

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