Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

A. Beck, Lisa; Thaçi, Diamant; D. Hamilton, Jennifer; M.H. Graham, Neil; Bieber, Thomas; E. Rocklin, Ross; E. Ming, Jeffrey; Ren, Haobo; Kao, Richard; L. Simpson, Eric; Ardeleanu, Marius; P. Weinstein, Steven; Pirozzi, Gianluca; Guttman‐Yassky, Emma; Suárez‐Fariñas, Mayte; Hager, Melissa; Stahl, Neil; D. Yancopoulos, George; Radin, Allen

doi:10.1056/nejmoa1314768

Public

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Published in New England Journal of Medicine • Jul 9, 2014

Authors:

Lisa A. Beck

Diamant Thaçi

Jennifer D. Hamilton

Abstract

BACKGROUND: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)-mediated inflammation could help in the treat...

Subject

Dupilumab

Atopic dermatitis

Medicine

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